The licensing checkpoint opens up

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A new pathway opens up on the study of lymphangiogenesis

Under the direction of Professor Agnès Noël, a team of scientists at the GIGA-Cancer research center of the University of Liège has developed, in collaboration with other European laboratories, a new lymphoangiogenesis model which could lead, among other things, to a better understanding of cancer cell dissemination (metastases). This finding is the subject of an article published in the renown...

FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer

Immunotherapy has had remarkable success in the treatment of some cancer types. However, pancreatic cancer has remained largely refractory to immunotherapy, including immune checkpoint inhibitors. Recently, Jiang and colleagues identified a key role for FAK in regulating the composition of the fibrotic and immuno-suppressive pancreatic tumour niche, and showed that FAK inhibitors can be used in...

A Book Which Opens Up Incredibly Interesting Material

As a specialist working on the history of the Islamic world and interested in documentary material, I had eagerly awaited this book, a book which would continue the chapters on Jewishwomen inGoitein’smagnumopus on the Jews of medieval Cairo based on Genizah documents.[1]What we now have is, indeed, a colorful insight into the world of Jewish women of sixteenth-century Palestine, based on an imp...

Structure that Opens the Gate and Opens the Door

Sometimes the best way to solve a problem is to look at it from a different perspective. That is certainly the case in ion channel research. Hodgkin and Huxley must have realized that 50 years ago when they looked at membrane currents with a voltage clamp, and Sakmann and Neher realized it 20 years ago when they measured Possible Symmetries of Tetrameric Channel single-channel currents with the...